Effect of external irradiation on the clearance and fate of transuranic oxides deposited in rat lung

Conference · Thu Aug 01 04:00:00 EDT 1985

OSTI ID:6386069

Rhoads, K; Geraci, J P; Mahaffey, J A; Killand, B W; Sanders, C L

Since internal exposures to radionuclides may also involve external radiation exposure, we initiated a series of studies to determine the fate of inhaled transuranic compounds in combination with external irradiation. For the first study, rats were irradiated in the thoracic region with a neutron or gamma source at doses comparable to those used for radiotherapy. Two to five months later, they wre exposed to a suspension of /sup 239/PuO/sub 2/ via inhalation or intratracheal instillation, and the clearance of radionuclide was compared to that in unirradiated rats. In a second study, rats received whole-body gamma exposures immediately before inhaling either /sup 239/Pu or /sup 244/Cm as high-fixed oxides. Exposure to 0.31-0.39 C/kg (1200-1500 R) of gamma or 9.5 Gy neutron irradiation months before inhalation inhibited the lung clearance of Pu, whereas whole-body irradiation immediately before inhalation exposure had little effect on clearance or translocation of Pu and Cm. 9 refs., 3 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA); Washington Univ., Seattle (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6386069
• Report Number(s): PNL-SA-12736; CONF-8509212-3; CONF-8509138-3; ON: DE85017931
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHALCOGENIDES
CLEARANCE
CURIUM 244
CURIUM COMPOUNDS
CURIUM ISOTOPES
CURIUM OXIDES
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
FERMIONS
GAMMA RADIATION
GLANDS
HADRONS
HEAVY NUCLEI
INFORMATION
INHALATION
INTAKE
IONIZING RADIATIONS
ISOTOPES
KIDNEYS
LIVER
LUNG CLEARANCE
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM 239
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SKELETON
TISSUE DISTRIBUTION
TRANSPLUTONIUM COMPOUNDS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES