Protective environment for marrow transplant recipients. A prospective study

Journal Article · Thu Nov 30 23:00:00 EST 1978 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-89-6-893· OSTI ID:6383160

Buckner, C D; Clift, R A; Sanders, J E; Meyers, J D; Counts, G W; Farewell, V T; Thomas, E D

Laminar air flow isolation and decontamination procedures were evaluated in a prospective randomized study in patients with aplastic anemia or acute leukemia undergoing marrow transplantation from HLA-matched siblings. Patients transplanted in the laminar air flow group had significantly less septicemia and major local infections than did patients in the control group. Nineteen of 46 laminar air flow patients and six of 44 control patients are alive at present. In patients with aplastic anemia the survival was 13 of 17 in the laminar air flow group compared with four of 17 in the control group. In patients with acute leukemia the survival was six of 29 in the laminar air flow group versus two of 27 in the control group. These differences were not statistically significant. Death in both the laminar air flow and control groups was predominantly due to interstitial pneumonitis or recurrent leukemia, which were unaffected by isolation and decontamination.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 6383160
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 89:6; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CLEANING
DECONTAMINATION
DISEASES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
LEUKEMIA
NEOPLASMS
ORGANS
PATIENTS
PNEUMONITIS
RADIATION EFFECTS
SEPTICEMIA
SURVIVAL TIME
SYMPTOMS
TISSUES
TRANSPLANTS