Radiation lesion to liver DNA of rats exposed to radiation during flight aboard the Kosmos-690 biosatellite. [Effect of weightlessness on. gamma. -radioinduced DNA strand breaks]

Journal Article · Thu Oct 26 00:00:00 EDT 1978 · Space Biol. Med. (USSR) (Engl. Transl.); (United States)

OSTI ID:6382375

Komolova, G S; Makeeva, V F; Egorov, I A; Tigranyan, R A; Grigor'ev, Yu G

A prime role is attributed to disturbances in DNA structure of nuclear chromatin as the mechanisms of radiation lesions in living cells. For this reason, it may be assumed that a change in the biological effectiveness of radiation delivered to animals under conditions that are extreme for vital functions, including space flight, may occur via modification of radiolesions in chromatin DNA. For this reason, the DNA of rats exposed to radiation from an onboard gamma source in the course of an actual space flight in the Kosmos-690 biosatellite was examined.

• OSTI ID: 6382375
• Journal Information: Space Biol. Med. (USSR) (Engl. Transl.); (United States), Vol. 12:5; Other Information: Translated from Kosm. Biol. i Aviakosmicheskaya Med.; 12: No. 5, 21-23(1978)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DNA
BIOLOGICAL RADIATION EFFECTS
STRAND BREAKS
SPACE FLIGHT
RADIOSENSITIVITY EFFECTS
RADIOINDUCTION
ANIMAL CELLS
BIOLOGICAL REPAIR
BIOSATELLITES
CESIUM 137
CHROMATIN
EXTERNAL IRRADIATION
GAMMA RADIATION
KOSMOS SATELLITES
LIVER
RATS
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
CESIUM ISOTOPES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
RODENTS
SATELLITES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560114* - Radiation Effects on Biochemicals- In Animals- (-1987)
560152 - Radiation Effects on Animals- Animals