Respiratory dust retention in small animals

Journal Article · Sun Jan 01 04:00:00 EST 1956 · AMA Arch. Ind. Health; (United States)

OSTI ID:6380726

Palm, P E; McNerney, J M; Hatch, T

Guinea pigs were indirectly measured for retention of 9 dusts (mean 0.1 to 3.0 ..mu..m) in various serial fractions. Total retention varies from approx. 90% for 3 ..mu..m dropping systematically with decreasing particle size to approx. 45% at 0.1 ..mu..m. Upper respiratory retention drops rapidly from approx. 70% at 3 ..mu..m to 10 to 20% at 1 ..mu..m or less. Alveolar retention drops somewhat with wide scatter from approx. 75 to approx. 50%. Alveolar deposition showed peak at approx. 1 ..mu..m. With monkeys, retention is similar to that of man although there is somewhat less deposition in 1 to 2 ..mu..m range. Retention was directly measured by killing experimental animals at different intervals after exposure to antimony trioxide dust and measuring antimony. Within 1 h after exposure, 80 to 82% was retained in entire system, 1/2 of which was in upper respiratory including bronchi. Retention after 6 h was approx. 45% in entire tract, 30% in upper tract alone, so lung retention was approx. 15% after 6 h. After 8 and up to 18 h, lung retention was about 10%, and that left in upper tract was only about 5% of original inhaled. Upper respiratory clearance was essentially completed in 2 to 6 h (subsiquent small removal from alveoli), so lung retention of 15% probably represents initial alveolar retention.Direct and indirect methods compared well. Smaller test animals have greater retention because of smaller dimensions of upper tract, especially the nose.

• OSTI ID: 6380726
• Journal Information: AMA Arch. Ind. Health; (United States), Journal Name: AMA Arch. Ind. Health; (United States) Vol. 13; ISSN AMIHA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMONY
ANTIMONY COMPOUNDS
ANTIMONY OXIDES
BODY
BODY AREAS
CHALCOGENIDES
CLEARANCE
DUSTS
ELEMENTS
EXCRETION
FACE
GUINEA PIGS
HEAD
LUNG CLEARANCE
LUNGS
MAMMALS
METALS
MONKEYS
NOSE
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PRIMATES
RESPIRATORY SYSTEM
RETENTION
RODENTS
VERTEBRATES