Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Phosphatidylinositol metabolism and /sup 45/Ca/sup 2 +/ efflux were examined in a vascular smooth muscle cell line (A7r5). (Arg 8)Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for /sup 45/Ca/sup 2 +/ efflux from preloaded cells. The efflux of /sup 45/Ca/sup 2 +/ in response to (Arg8)vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilization from an intracellular source in cultured vascular smooth muscle cells.
- Research Organization:
- Sandoz Ltd., Basel, Switzerland
- OSTI ID:
- 6378361
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Fri Feb 28 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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OSTI ID:5322865
Related Subjects
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CALCIUM 45
CALCIUM ISOTOPES
CARBOHYDRATES
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HORMONES
INOSITOL
INOSITOLS
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPES
KINETICS
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
MONOSACCHARIDES
MUSCLES
NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
VASOPRESSIN
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CALCIUM 45
CALCIUM ISOTOPES
CARBOHYDRATES
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HORMONES
INOSITOL
INOSITOLS
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPES
KINETICS
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
MONOSACCHARIDES
MUSCLES
NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
VASOPRESSIN
VERTEBRATES