Evaluation of ileal function using 23-selena-25-homotaurocholate, a-gamma-labeled conjugated bile acid. Initial clinical assessment

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Gastroenterology; (United States)

OSTI ID:6377777

Nyhlin, H; Merrick, M V; Eastwood, M A; Brydon, W G

23-Selena-25-homotaurocholate is a synthetic bile acid labeled with a gamma-ray-emitting radioisotope /sup 75/Se. It is readily measured using external detectors and is thus suitable for whole-body counting. Whole-body retention was measured at 0, 4, and 7 days after oral administration to normal controls and to patients with disease of the small intestine, colon, or ileocecal region. Whole-body retention of less than 25% of the administered radioactivity within 4 days is definitely abnormal, but there was overlap between normal and abnormal groups at this time. At 7 days, whole-body retention less than 12% is abnormal and greater than 19% is normal. Between these limits, values may represent minimal ileal dysfunction not demonstrable by older techniques. Excretion of 23-selena-25-homotaurocholate follows a biexponential curve. The faster component has a half-life similar to that of natural bile acid. It is uncertain whether the slower component represents a hitherto unrecognized slowly turning over pool of bile acid or is a metabolic product of 23-selena-25-homotaurocholate not yet identified in vitro. There is a significant relationship between the whole-body retention of 23-selena-25-homotaurocholate and total fecal and primary bile acids. 23-selena-25-homotaurocholate is simple and acceptable for investigating ileal function.

• Research Organization: Department of Medicine, Western General Hospital, Edinburgh, Scotland
• OSTI ID: 6377777
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 84:1; ISSN GASTA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BILE ACIDS
BIOCHEMISTRY
BODY
CARBOXYLIC ACIDS
CHEMISTRY
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
LABELLED COMPOUNDS
LARGE INTESTINE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIOISOTOPES
RETENTION
SELENIUM 75
SELENIUM ISOTOPES
SMALL INTESTINE
STEROIDS
STEROLS
USES
WHOLE-BODY COUNTING