Enterohepatic circulation in man of a gamma-emitting bile-acid conjugate, 23-selena-25-homotaurocholic acid (SeHCAT)

Journal Article · Mon Feb 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:5478227

Merrick, M V; Eastwood, M A; Anderson, J R; Ross, H M

A conjugated bile acid, 23-selena-25-homotaurocholic acid (SeHCAT), labeled with the gamma emitter Se-75, has been evaluated in man. Absorption and excretion were compared with that of simultaneously administered (23-14C)cholic acid. SeHCAT is absorbed quantitatively following oral administration, secreted into the bile at the same rate as cholic acid, reabsorbed from the small intestine, and resecreted. It is not absorbed when the terminal ileum has been excised or bypassed. SeHCAT is therefore the first of a new class of radiopharmaceuticals, namely, gamma-emitting tracers of the complete cycle of the enterohepatic circulation. Its use will simplify investigation of the functional state of the terminal ileum by eliminating the need to collect and process feces.

• OSTI ID: 5478227
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
BETA DECAY RADIOISOTOPES
BILE ACIDS
BLOOD CIRCULATION
CARBOXYLIC ACIDS
CHEMICAL PROPERTIES
CHOLIC ACID
CLEARANCE
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
METABOLISM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SELENIUM 75
SELENIUM ISOTOPES
STEROIDS
STEROLS