Angiotensin II inhibits cortical cholinergic function: Implications for cognition

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Journal of Cardiovascular Pharmacology; (USA)

DOI:https://doi.org/10.1097/00005344-199008000-00009· OSTI ID:6374373

Barnes, J M; Barnes, N M; Costall, B; Horovitz, Z P; Ironside, J W; Naylor, R J; Williams, T J ^[1]

---

1. Univ. of Bradford (England)

In the present studies we have shown that angiotensin II (AT II), in a concentration-dependent manner in rat tissue (10(-9)-10(-5) M) or at a single concentration in human tissue (10(-6) M), can inhibit potassium-stimulated release of (3H)acetylcholine ( (3H)Ach) from slices of rat entorhinal cortex and human temporal cortex preloaded with (3H)choline for the biochemical analyses. The inhibitory effects of AT II (10(-6) M) were antagonised by the specific AT II receptor antagonist (1-sarcosine, 8-threonine)AT II in a concentration-dependent manner in rat tissue (10(-11)-10(-8) M) and at the single concentration employed in the human studies (10(-7) M). Also demonstrated were other components of the angiotensin system in the human temporal cortex; ACE activity was present (1.03 nmol min-1 mg-1 protein), as were AT II recognition sites (Bmax = 8.6 fmol mg-1 protein). It is hypothesised that the potential cognitive enhancing properties of ACE inhibitors may reflect their action to prevent the formation of AT II and so remove an inhibitory modulator of cholinergic function.

• OSTI ID: 6374373
• Journal Information: Journal of Cardiovascular Pharmacology; (USA), Vol. 16:2; ISSN 0160-2446
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
SECRETION
ANGIOTENSIN
BIOCHEMICAL REACTION KINETICS
ANIMAL TISSUES
CEREBRAL CORTEX
CHOLINE
DOSE-RESPONSE RELATIONSHIPS
INHIBITION
MAN
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DRUGS
ESTERS
GLOBULINS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LIPOTROPIC FACTORS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PRIMATES
PROTEINS
QUATERNARY COMPOUNDS
REACTION KINETICS
RODENTS
TISSUES
VASOCONSTRICTORS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques