Doxorubicin cardiomyopathy in children with left-sided Wilms tumor
Journal Article
·
· Med. Pediatr. Oncol.; (United States)
OSTI ID:6373984
Two children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopathy after irradiation to the tumor bed and conventional dosage of doxorubicin. The cardiomyopathy is attributed 1) to the fact that radiation fields for left Wilms tumor include the lower portion of the heart and 2) to the interaction of doxorubicin and irradiation on cardiac muscle. It is recommended that doxorubicin dosage be sharply restricted in children with Wilms tumor of the left kidney who receive postoperative irradiation.
- Research Organization:
- Division of Pediatrics, City of Hope National Medical Center, Duarte, California
- OSTI ID:
- 6373984
- Journal Information:
- Med. Pediatr. Oncol.; (United States), Journal Name: Med. Pediatr. Oncol.; (United States) Vol. 10:5; ISSN MPOND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CHILDREN
DISEASES
DOXORUBICIN
DRUGS
HEART
IRRADIATION
KIDNEYS
LOCAL IRRADIATION
MEDICINE
MUSCLES
MYOCARDIUM
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PEDIATRICS
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
THERAPY
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CHILDREN
DISEASES
DOXORUBICIN
DRUGS
HEART
IRRADIATION
KIDNEYS
LOCAL IRRADIATION
MEDICINE
MUSCLES
MYOCARDIUM
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PEDIATRICS
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
THERAPY