Effects of fly ash inhalation on murine immune function: effects on systemic response

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90136-0· OSTI ID:6373607

Eskew, M L ^[1]; Zarkower, A; Scheuchenzuber, W J; Graham, J A

---

1. Pennsylvania State Univ., University Park

Mice were exposed to fly ash at levels ranging from 728-2221 ..mu..g/m/sup 3/ respirable for varying periods of time, and several immunological parameters were measured. Little change was noted in splenic response to mitogens or cytolytic ability. Splenic lymphocytes from fly ash-exposed mice incorporated significantly more thymidine following subcutaneous sensitization with BCG, although no differences were noted in response of these lymphocytes to PPD. Fly ash exposure of greater than 1 week caused a suppression of antibody response to aerosols of Escherichia coli in the spleen, but not in the mediastinal lymph nodes. Following 3-4 weeks of fly ash exposure, no changes in splenic antibody responses were noted following intravenous injections of LPS or intratracheal injections of DNP-Ficoll. However, after 9 months exposure at higher concentrations of fly ash, splenic plaque-forming responses were significantly suppressed after both aerosol and intratracheal exposure to antigen.

• OSTI ID: 6373607
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 28:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMAL CELLS
ANIMALS
ANTIBODIES
ASHES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
FLY ASH
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
INHALATION
INHIBITION
INTAKE
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RESIDUES
RIBOSIDES
RODENTS
SOMATIC CELLS
SPLEEN
THYMIDINE
VERTEBRATES
WASTES