Mitogen stimulation of lymphocytes in CBA mice exposed to lead and cadmium
CBA mice were exposed to lead acetate or cadmium chloride in drinking water for 10 weeks. Selected groups of these animals were also injected with Bacillus Calmette-Guerin (BCG) during exposure of the metals. The ability of mitogens concanavalin A (Con A) and lipopolysaccharide (LPS) as well as purified protein derivative (PPD) to induce proliferation of splenic lymphocytes was assessed. In general, lead tended to inhibit lymphocyte proliferation by LPS and PPD while cadmium potentiated blastogenesis by the mitogens. The two larger doses of cadmium, 30 and 300 ppM, resulted in intense proliferation which was significant (P < 0.05) for the non-BCG, 300-ppM cadmium group. However, 3 ppM cadmium reduced the lymphocyte response to LPS and PPD which was significant (P < 0.05) for the non-BCG-injected mice. Lead and cadmium did not significantly affect the response of lymphocyte proliferation by Con A. Group variation and interpretation of data are discussed.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 5406720
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 19:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CADMIUM
CELL DIVISION
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
ELEMENTS
EXPERIMENTAL DATA
IMMUNE REACTIONS
INFORMATION
ISOLATED VALUES
LEAD
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METALS
MICE
MITOSIS
MITOTIC INDEX
NUMERICAL DATA
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES