Clinical comparison of /sup 99m/Tc HEDP and /sup 99m/Tc MDP in the detection of bone metastases: concise communication. [Comparative effectiveness of 2 phosphoric acid ster radiopharmaceuticals]
We have compared bone scintigrams made with /sup 99m/Tc-tagged HEDP (1-hydroxy-ethylidene diphosphonate) and MDP (methyl diphosphonate), the former at 4 hr after injection, the latter at both 2 and 4 hr. In 17 patients with skeletal metastases, there was no significant difference in lesion count or scan quality between the 4-hr images. The tumor-to-bone ratio (T/B) was significantly higher with Tc-HEDP (p < 0.02). Lesion detection rate and T/B ratios were both lower with Tc-MDP at 2 hr when compared with the 4-hr values for both Tc-HEDP (p < 0.02, p < 0.005) and Tc-MDP (p < 0.02, p < 0.01). The 4-hr Tc-MDP scan was of significantly higher quality than the 2 hr Tc-MDP scan (p < 0.01). Although Tc-HEDP produces a higher T/B ratio at 4 hr, the present study does not suggest that either agent is superior in clinical practice.
- Research Organization:
- Glasgow Royal Infirmary, Glasgow, Scotland
- OSTI ID:
- 6371828
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:2
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
METASTASES
DIAGNOSIS
PHOSPHORIC ACID ESTERS
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
SKELETON
SCINTISCANNING
TECHNETIUM 99
EXPERIMENTAL DATA
ISOLATED VALUES
ISOMERIC NUCLEI
PATIENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DRUGS
ESTERS
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)