A comparison of bone imaging with Tc-99m DPD and Tc-99m MDP: concise communication
Bone to soft tissue (ST) ratios for both high-uptake bone (sacrum) and low-uptake bone (femoral diaphysis) were obtained with a derivative of phosphonic acid, TC-99m 2,3-dicarboxypropane-1, 1-diphosphonate (DPD), in 26 normal subjects and 177 patients with malignant disease but without metastases. Tests were run 2 hr after tracer injection. Similar ratios were obtained with Tc-99m methylene diphosphonate (MDP) in 220 normal subjects and 451 patients. With MDP, the influence of incubation time (5-10 min in 416 cases, 45 min in 185 cases) on these ratios was determined. DPD was superior to MDP for both ratios. With MDP, prolonged incubation time yielded significantly enhanced ratios; however, the ratios for the DPD were still higher. With either agent and preparation, sacrum-to-ST ratios decreased with increasing subject age, and in patients with malignant disease the ratios tended to be higher than those obtained from normals.
- Research Organization:
- Klinikum Grosshadern, University of Munich, Federal Republic of Germany
- OSTI ID:
- 5310333
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE TISSUES
SCINTISCANNING
TECHNETIUM 99
RADIOPHARMACEUTICALS
ISOMERIC NUCLEI
NEOPLASMS
SKELETON
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics