Polychlorinated biphenyl uptake and transport by lymph and plasma components

Journal Article · Wed May 01 04:00:00 EDT 1985 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-179-42073· OSTI ID:6371597

Busbee, D L; Yoo, J S.H.; Norman, J O; Joe, C O

The uptake and vascular transport of ingested Aroclor 1242, an isomeric mixture of polychlorinated biphenyls (PCB), was investigated in experimental animals. High concentrations of ingested PCB were found in the chylomicron fraction of thoracic duct lymph. When the lymph flow was exteriorized PCB were not subsequently found in the vascular circulation. When lymph was not exteriorized plasma PCB concentrations reached maximal levels 6 hr after ingestion. Less than 1% of total plasma PCB was detected in cellular fractions of blood over a 10-hr period following ingestion. Chylomicrons contained 31% of total plasma PCB 30 min after ingestion, decreasing to less than 6% at 4 hr. A maximum of 10% of plasma PCB at 1 hr, and <5% at 6 hr, after ingestion was associated with very low density lipoproteins (VLDL) or low density lipoproteins (LDL). Although PCB enter the vascular circulation with the chylomicron fractions of lymph, delipoproteinated plasma contained 52% of the total PCB in blood collected 30 min after ingestion. This level increased to 78% after 2 hr, and remained constant at about 80% for an additional 8-hr period.

• Research Organization: Texas A and M Univ., College Station
• OSTI ID: 6371597
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 179:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CHLORINATED AROMATIC HYDROCARBONS
CHYLOMICRONS
DATA
DISTRIBUTION
EXPERIMENTAL DATA
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
INTESTINAL ABSORPTION
LABORATORY ANIMALS
LIPIDS
LIPOPROTEINS
LYMPH
MATERIALS
METABOLISM
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PROTEINS
TISSUE DISTRIBUTION
UPTAKE