Benzo(a)pyrene uptake by lymph: a possible transport mode for immunosuppressive chemicals

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530480· OSTI ID:6118240

Busbee, D L; Joe, C O; Rankin, P W; Ziprin, R L; Wilson, R D

Benzo(a)pyrene, a lipophilic promutagen, reached maximal concentrations in the thoracic duct lymphatic circulation within 2 h after gastric instillation. Benzo(a)pyrene in lymph obtained by thoracic duct cannulation decreased to approximately control levels within 4 h after treatment. When lymph was not allowed to enter the blood vascular circulation, serum levels of benzo(a)pyrene increased very slowly, suggesting minimal mesenteric blood vascular absorption of the lipophilic hydrocarbon. Benzo(a)pyrene partitions into lymph lipoproteins as a function of the lipoprotein concentration. Data suggest that low-density lipoproteins may take up benzo(a)pyrene more efficiently than do very low-density or high-density lipoproteins, and that lymph components other than lipoproteins do not take up and transport benzo(a)pyrene. We propose that lipophilic xenobiotic compounds interact with cells of the immune system via lymphatic lipoprotein transport of potentially mutagenic, carcinogenic, or immuno-suppressive agents.

• Research Organization: Texas A and M Univ., College Station
• OSTI ID: 6118240
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:1; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CONDENSED AROMATICS
DOMESTIC ANIMALS
HYDROCARBONS
KINETICS
LIPIDS
LIPOPROTEINS
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PROTEINS
REACTION KINETICS
RUMINANTS
SHEEP
UPTAKE
VERTEBRATES