Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors

Journal Article · Sun Feb 01 00:00:00 EST 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.3.842· OSTI ID:6370953

Schweigerer, L; Neufeld, G; Mergia, A; Abraham, J A; Fiddes, J C; Gospodarowicz, D

Cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor (bFGF) gene and they produced bFGF, which is apparently composed of two microheterogenous forms with M/sub r/s of 16,500 and 17,200, respectively. bFGF was purified by radioreceptor binding assays or cross-linking experiments. bFGF derived from the rhabdomyosarcoma cells stimulates their own proliferation and that of human or bovine vascular endothelial cells. It is conceivable that the rhabdomyosarcoma-derived bFGF stimulates the growth and neovascularization of human rhabdomyosarcomas and that it may thereby contribute to the development of these tumors.

• Research Organization: Univ. of California Medical Center, San Francisco
• OSTI ID: 6370953
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
PROTEINS
RADIORECEPTOR ASSAY
TUMOR CELLS
CELL PROLIFERATION
BLOOD VESSELS
CROSS-LINKING
FIBROBLASTS
GROWTH
IODINE 125
MAN
RHABDOMYOSARCOMAS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MYOSARCOMAS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYMERIZATION
PRIMATES
RADIOISOTOPES
SARCOMAS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics