Pituitary follicular cells produce basic fibroblast growth factor
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, has been identified as basic fibroblast growth factor (bFGF). These data indicate that follicular cells may be a major source of bFGF in the pituitary gland. Considering that bFGF has been proposed to play a role in paracrine regulation of pituitary hormone secretion, the data also suggest that these cells may exert important local regulatory functions.
- Research Organization:
- Univ. of California Medical Center, San Francisco (USA)
- OSTI ID:
- 5293998
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:16
- Country of Publication:
- United States
- Language:
- English
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· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5293998
Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor
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·
Mon May 01 00:00:00 EDT 1989
· In Vitro Cellular and Developmental Biology; (USA)
·
OSTI ID:5293998
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
GROWTH FACTORS
RADIOIMMUNOASSAY
RADIORECEPTOR ASSAY
SOMATIC CELLS
MORPHOLOGY
CATTLE
FIBROBLASTS
PITUITARY GLAND
PURIFICATION
ANIMAL CELLS
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
ENDOCRINE GLANDS
GLANDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RUMINANTS
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
GROWTH FACTORS
RADIOIMMUNOASSAY
RADIORECEPTOR ASSAY
SOMATIC CELLS
MORPHOLOGY
CATTLE
FIBROBLASTS
PITUITARY GLAND
PURIFICATION
ANIMAL CELLS
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
ENDOCRINE GLANDS
GLANDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RUMINANTS
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics