Assessment of the mutagenic potential of ethanol auto engine exhaust gases by the Salmonella typhimurium microsomal mutagenesis assay, using a direct exposure method
Journal Article
·
· Environmental Research; (USA)
- Univ. of Sao Paulo (Brazil)
The mutagenic activity of the new Brazilian fuel, ethanol, was determined by employing the Salmonella typhimurium microsomal mutagenesis assay (TA97, TA98, TA100, TA102, and TA104) and a direct exposure method. This methodology was first used to determine the mutagenic activity of gasoline, revealing mutagenic activity of base-pair substitution without any need for metabolic activation, indicating the presence of direct-action mutagens. Experiments with ethanol suggest an indirect mutagenic activity of the oxidant type. The exposure system was considered suitable for future studies of gaseous mixtures.
- OSTI ID:
- 6364396
- Journal Information:
- Environmental Research; (USA), Journal Name: Environmental Research; (USA) Vol. 52:2; ISSN ENVRA; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AUTOMOBILES
BACTERIA
BODY
CELL CONSTITUENTS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ETHANOL
EXHAUST GASES
FLUIDS
FUELS
GASEOUS WASTES
GASES
GASOLINE
GLANDS
HYDROXY COMPOUNDS
LIQUID FUELS
LIVER
MICROORGANISMS
MICROSOMES
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PETROLEUM PRODUCTS
RIBOSOMES
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
VEHICLES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AUTOMOBILES
BACTERIA
BODY
CELL CONSTITUENTS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ETHANOL
EXHAUST GASES
FLUIDS
FUELS
GASEOUS WASTES
GASES
GASOLINE
GLANDS
HYDROXY COMPOUNDS
LIQUID FUELS
LIVER
MICROORGANISMS
MICROSOMES
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PETROLEUM PRODUCTS
RIBOSOMES
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
VEHICLES
WASTES