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Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells

Journal Article · · Blood; (United States)
OSTI ID:6364270
; ;

A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. He remained in complete remission for 18 mo, when he developed a chloroma in the perineum. The chloroma was treated with local radiotherapy. The chloroma recurred 8 mo later and was treated with radiotherapy followed by combination chemotherapy. At 34 mo after transplant, marrow relapse and chloroma were documented. The first chloroma contained host cells by fluorescent Y-chromatin body analyses of interphase nuclei. All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. A new consistent chromosome abnormality (45, X, -X, t(8;21) (q22; q22)) was observed in a majority of donor cells. The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment.

OSTI ID:
6364270
Journal Information:
Blood; (United States), Journal Name: Blood; (United States) Vol. 52:3; ISSN BLOOA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550300 -- Cytology
550400 -- Genetics
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
BIOCHEMISTRY
BIOLOGY
BODY
BONE MARROW
CHEMISTRY
CHEMOTHERAPY
CHROMOSOMAL ABERRATIONS
DISEASES
GENETICS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
LEUKEMIA
MEDICINE
MUTATIONS
MYELOID LEUKEMIA
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
THERAPY
TISSUES
TRANSPLANTS
TUMOR CELLS