The relative roles of MHC and non-MHC antigens in bone marrow transplantation in rats. Graft acceptance and antigenic expression on donor red blood cells

Journal Article · Wed Jun 01 04:00:00 EDT 1983 · Transplantation; (United States)

OSTI ID:5514276

Pinto, M; Gill, T J; Kunz, H W; Dixon-McCarthy, B D

In order to investigate the influence of MHC and non-MHC genes in bone marrow transplantation, various combinations of congenic and inbred strains of rats were used as donors and recipients. A standard regimen of busulfan and cyclophosphamide treatment was used to condition the recipients. The resultant survival patterns of the animals indicated that: (1) a difference across the entire RT1 (MHC) complex is sufficient for the induction of fatal graft-versus-host disease (GVHD) in 100% of the engrafted animals; and (2) the blood group antigens RT2 and RT3, which are controlled by non-MHC genes, do not cause bone marrow graft rejection or GVHD. There were sequential changes of expression in surface alloantigens on the red cells in different donor-recipient combinations without other hematologic changes in the busulfan-cyclophosphamide conditioned bone marrow chimeras.

• Research Organization: Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania
• OSTI ID: 5514276
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 35:6; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CHIMERAS
GENES
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
IMMUNOSUPPRESSION
MAMMALS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIOIMMUNOLOGY
RATS
RODENTS
TISSUES
TRANSPLANTS
VERTEBRATES