The relative roles of MHC and non-MHC antigens in bone marrow transplantation in rats. Graft acceptance and antigenic expression on donor red blood cells
In order to investigate the influence of MHC and non-MHC genes in bone marrow transplantation, various combinations of congenic and inbred strains of rats were used as donors and recipients. A standard regimen of busulfan and cyclophosphamide treatment was used to condition the recipients. The resultant survival patterns of the animals indicated that: (1) a difference across the entire RT1 (MHC) complex is sufficient for the induction of fatal graft-versus-host disease (GVHD) in 100% of the engrafted animals; and (2) the blood group antigens RT2 and RT3, which are controlled by non-MHC genes, do not cause bone marrow graft rejection or GVHD. There were sequential changes of expression in surface alloantigens on the red cells in different donor-recipient combinations without other hematologic changes in the busulfan-cyclophosphamide conditioned bone marrow chimeras.
- Research Organization:
- Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania
- OSTI ID:
- 5514276
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 35:6; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CHIMERAS
GENES
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
IMMUNOSUPPRESSION
MAMMALS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIOIMMUNOLOGY
RATS
RODENTS
TISSUES
TRANSPLANTS
VERTEBRATES