Structural chromosome aberrations in lymphocytes from children previously treated for Wilms' tumor or Hodgkin's disease

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Pediatric Hematology and Oncology; (USA)

DOI:https://doi.org/10.3109/08880018909034275· OSTI ID:6359782

Brogger, A; Kolmannskog, S; Nicolaysen, R B; Wesenberg, F; Nygaard, R ^[1]

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1. Norwegian Radium Hospital, Montebello, Oslo (Norway)

Nineteen children treated for Wilms' tumor (thirteen cases) or Hodgkin's disease (six cases) with cytostatic agents and/or radiotherapy were studied cytogenetically on lymphocytes cultivated from blood samples drawn after at least 1 year of complete remission after end of therapy. A reference group of children was matched for age, sex, and residence. The frequencies of sister chromatid exchange (5.4 versus 5.6 SCE/cell), and chromosome damage type gaps (6.6 versus 7.1%) and breaks (1.9 versus 1.9%) were not different in the two groups, but exchange type aberrations were more frequent in the patients (0.9 versus 0.06%). Fifty karyotypes were analyzed in all but two cases of Hodgkin's disease. The overall frequency of stable (3.1 versus 3.8%) and unstable (1.7 versus 1.4%) structural chromosome changes such as translocations, deletions, chromatid exchanges, and dicentrics were not different in the patient and the control groups. If the chromosome data reflect a general cancer risk, this risk cannot be considerably higher among the cancer-treated children.

• OSTI ID: 6359782
• Journal Information: Pediatric Hematology and Oncology; (USA), Journal Name: Pediatric Hematology and Oncology; (USA) Vol. 6:2; ISSN PHONE; ISSN 0888-0018
• Country of Publication: United States
• Language: English

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