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Hypoxic radiosensitization by the antimicrobial methyl paraben

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

The antimicrobial preservative, methyl paraben (methyl-4-hydroxybenzoate) sensitizes anoxic buffered suspensions of Staphylococcus aureus to gamma-radiation. The maximal response at an 0.5 mM concentration represents a 150 percent increase in response over that for deoxygenated suspensions without additive, and 80 percent of the response for aerated suspensions alone. Methyl paraben is not toxic to the test organism under the present test conditions.

Research Organization:
Hebrew Univ. of Jerusalem, Israel
OSTI ID:
6354534
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:8; ISSN IOBPD
Country of Publication:
United States
Language:
English

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