Radiosensitization of Staphylococcus aureus by secobarbital sodium and other barbiturates
The barbiturate hypnotic, secobarbital sodium, at millimolar concentrations, sensitizes Staphylococcus aureus in anoxic buffer-saline suspension (pH 7.0) to the lethal effects of ..gamma.. rays. The maximal response represents 50% of that for oxygenated suspensions without additive. Secobarbital sodium operates within the oxygen effect. It must be present at the time of irradiation for modification of radiation response. This, coupled with its testing in the presence of other additives, points to its involvement in an intracellular reaction with a radiation-induced short-lived chemical species, probably the electron. Preliminary tests show that pentobarbital sodium also operates as an efficient hypoxic radiosensitizer. Lack of sensitization by phenobarbital sodium is attributed to its low lipid solubility.
- Research Organization:
- Hebrew Univ. of Jerusalem, Israel
- OSTI ID:
- 5653295
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 96:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
AZINES
BACTERIA
BARBITURATES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CELL KILLING
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COBALT 60
COBALT ISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHARMACOLOGY
PYRIMIDINES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
STAPHYLOCOCCUS
SURVIVAL CURVES
YEARS LIVING RADIOISOTOPES