Chromosomal organization of the human major histocompatibility complex class I gene family
Journal Article
·
· J. Exp. Med.; (United States)
17 HLA class I genes have been isolated from the genome of B-lymphoblastoid cell line 721. Sequence analysis and transfection studies indicate that three genes, in addition to those encoding the HLA-A, -B, and -C antigens can direct the synthesis of a class I alpha protein (4, 5, 21). Using gene-specific DNA probes to analyze the presence of restriction fragment-length polymorphisms within a large pedigree and in panel of HLA deletion mutant cell lines, we show here that two of these genes, designated HLA-G and HLA-F, are located on the short arm of chromosome 6 telomeric to the HLA-A locus. The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA-A and HLA-C (4). In addition, the remaining 11 class I pseudogenes and gene fragments are localized relative to established markers on chromosome 6p.
- Research Organization:
- Univ. of Minnesota, Minneapolis (USA)
- OSTI ID:
- 6353971
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 169:2; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
The HLA class I gene family includes at least six genes and twelve pseudogenes and gene fragments
Structure, expression, and molecular mapping of a divergent member of the class I HLA gene family
Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells
Journal Article
·
Tue Sep 15 00:00:00 EDT 1992
· Journal of Immunology; (United States)
·
OSTI ID:7009405
Structure, expression, and molecular mapping of a divergent member of the class I HLA gene family
Journal Article
·
Mon Jun 01 00:00:00 EDT 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5445599
Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells
Journal Article
·
Thu Dec 31 23:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6464555