Steroid metabolism by monkey and human spermatozoa

Journal Article · Sun May 01 00:00:00 EDT 1983 · Steroids; (United States)

DOI:https://doi.org/10.1016/0039-128X(83)90024-7· OSTI ID:6353759

Rajalakshmi, M; Sehgal, A; Pruthi, J S; Anand-Kumar, T C

Freshly ejaculated spermatozoa from monkey and human were washed and incubated with tritium labelled androgens or estradiol to study the pattern of spermatozoa steroid metabolism. When equal concentrations of steroid substrates were used for incubation, monkey and human spermatozoa showed very similar pattern of steroid conversion. Spermatozoa from both species converted testosterone mainly to androstenedione, but reverse conversion of androstenedione to testosterone was negligible. Estradiol-17 beta was converted mainly to estrone. The close similarity between the spermatozoa of monkey and men in their steroid metabolic pattern indicates that the rhesus monkey could be an useful animal model to study the effect of drugs on the metabolic pattern of human spermatozoa.

• Research Organization: All India Inst. of Medical Sciences, New Delhi
• OSTI ID: 6353759
• Journal Information: Steroids; (United States), Journal Name: Steroids; (United States) Vol. 41:5; ISSN STEDA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MODELS
GAMETES
GERM CELLS
IN VITRO
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MAN
METABOLISM
MONKEYS
ORGANIC COMPOUNDS
PRIMATES
REACTION KINETICS
SPERMATOZOA
STEROIDS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES