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Relationship between histologic type of primary lung cancer and carbon-11-L-methionine uptake with positron emission tomography

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6353576
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L-(Methyl-/sup 11/C)-methionine ((/sup 11/C)methionine) has proved to be one of the useful amino acids for the diagnosis of human cancer. We examined whether there was any correlation between (/sup 11/C)methionine uptake and histologic type of primary lung cancer. Sixteen patients with nine squamous cell carcinoma, five large cell carcinoma, one small cell carcinoma, and one adenocarcinoma were studied using positron emission tomography (PET). All patients had high accumulation of (/sup 11/C)methionine in lung tumors. We evaluated (/sup 11/C)methionine uptake into the tumor by a semiquantitative value, DUR (Differential Uptake Ratio). There was significant difference (p less than 0.01, Mann-Whitney test) of (/sup 11/C)methionine uptake between large cell carcinoma (3.98 +/- 0.27) and squamous cell carcinoma (2.92 +/- 0.30). The result suggested that there was correlation between (/sup 11/C)methionine accumulation and the histologic type of lung cancer. This indicates a new potential applicability of (/sup 11/C)methionine PET for the study of lung cancer.

Research Organization:
Tohoku Univ. (Japan)
OSTI ID:
6353576
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:1; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPOTROPIC FACTORS
LUNGS
METHIONINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
TOMOGRAPHY
UPTAKE