Metabolism of 2-naphthylamine and benzidine by rat and human bladder organ cultures

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/5.7.949· OSTI ID:6352349

Moore, B P; Potter, P M; Hicks, R M

The metabolism of benzidine and 2-naphthylamine, two aromatic amines which are carcinogenic for the human, was investigated in human and rat bladder organ cultures. There was little oxidative metabolism of either carcinogen in either species. In particular, N-hydroxy-2-naphthylamine, a proximate carcinogen of 2-naphthylamine could not be detected. In contrast, large amounts of the acetylated metabolites, N-acetylbenzidine, N,N-diacetylbenzidine and N-acetyl-2-naphthylamine were formed both in rat and human bladder cultures. The results suggest that metabolism of these carcinogens in situ in the bladder is unlikely to contribute to their carcinogenic effect but instead may have a positive protective role.

• Research Organization: Middlesex Hospital Medical School, London, England
• OSTI ID: 6352349
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5:7; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
BENZIDINE
BLADDER
BODY
CARCINOGENESIS
LABELLED COMPOUNDS
MAMMALS
MAN
METABOLISM
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PRIMATES
RATS
RODENTS
TISSUE CULTURES
TRITIUM COMPOUNDS
URINARY TRACT
VERTEBRATES