Respiratory function responses of animals and man to oxidant gases and to pulmonary emphysema

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530502· OSTI ID:6352248

Mauderly, J L

Data on the respiratory functional responses of animals and humans to inhaled oxidant gases and to pulmonary emphysema were reviewed and compared. Comparisons included responses to short-term inhalation of ozone, nitrogen dioxide, and oxygen and the functional manifestations of chronic emphysema. The comparisons illustrated that animals and humans have qualitatively similar functional responses to the irritant, bronchoconstrictive, and sensitizing effects of acutely inhaled ozone and nitrogen dioxide. Animals and humans responded similarly to the inflammatory and edematous effects of inhaled oxygen. Similar changes in maximal expiratory flow-volume curves, pressure-volume curves, lung volumes, and alveolar-capillary gas exchange occurred in animals and humans with emphysema. These results suggest that similar respiratory functional changes occur in both animals and humans when similar morphological changes result from lung injury. This observation lends confidence to the use of laboratory animals in studies to predict the effects of long-term exposure of humans to inhaled oxidant gases. 42 references.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6352248
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:2-3; ISSN JTEHD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
CHALCOGENIDES
COMPARATIVE EVALUATIONS
DOCUMENT TYPES
ELEMENTS
FUNCTIONS
INJURIES
LABORATORY ANIMALS
LUNGS
MAMMALS
MAN
MORPHOLOGICAL CHANGES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NONMETALS
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
OZONE
PRIMATES
RESPIRATORY SYSTEM
REVIEWS
VERTEBRATES