Potential of palladium-109-labeled antimelanoma monoclonal antibody for tumor therapy. [Mice]

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · J. Nucl. Med.; (United States)

OSTI ID:6349485

Fawwaz, R A; Wang, T S; Srivastava, S C; Rosen, J M; Ferrone, S; Hardy, M A; Alderson, P O

Palladium-109, a beta-emitting radionuclide, was chelated to the monoclonal antibody 225.28S to the high molecular weight antigen associated with human melanoma. The radiolabeled antibody maintained its specific in vitro reactivity with cultured human melanoma cells. Injection of the radiolabeled monoclonal antibody into nude mice bearing human melanoma resulted in significant accumulation of the radiolabel in the tumors: 19% injected dose/g; 38:1 and 61:1 tumor-to-blood ratios at 24 and 48 hr, respectively. The localization of the radiolabeled antibody in liver and kidney also was high, but appreciably lower than that achieved in tumor. These results suggest that Pd-109-labeled monoclonal antibody to tumor-associated antigens may have potential applications in tumor immunotherapy.

• Research Organization: Columbia Univ., New York, NY
• OSTI ID: 6349485
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CELL CULTURES
DIGESTIVE SYSTEM
DISEASES
EVEN-ODD NUCLEI
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLING
LIVER
MAMMALS
MAN
MELANOMAS
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ORGANS
PALLADIUM 109
PALLADIUM ISOTOPES
PRIMATES
RADIOISOTOPES
RODENTS
THERAPY
USES
VERTEBRATES