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Late skin damage in rabbits and monkeys after exposure to particulate radiations

Conference · · Adv. Space Res.; (United States)
OSTI ID:6347839
;
Preliminary results are reported of experiments on the late effects of exposure to particulate radiations on stem cell populations. Skin biopsies were taken from the ears of rabbits irradiated 2-5 years previously with 530 MeV/amu Ar ions (LET 90 keV/micron), or 365 MeV/amu Ne ions (LET 35 keV micron), and from the chests and inner thighs of rhesus monkeys irradiated 16-18 years previously with 32-MeV protons (LET about 1.2 keV/micron). Skin fibroblast cultures obtained from the biopsy samples in rabbits were observed to undergo dose-dependent decreases in in vitro life span, with estimated survival curves showing the effects of Ar-ion irradiation to be more severe than those of Ne-ion irradiation. In addition, the healing of the biopsy wound was observed to become slower as radiation dose increased. In the monkey, radiation reduced the average number of fibroblasts at the time of cessation of growth in culture. Results thus demonstrate the capacity of skin sampling to reveal stem cell destruction, and have important implications for astronauts and other persons at risk of particle exposure with regard to healing responses to trauma or surgery. 27 references.
Research Organization:
Colorado State Univ., Fort Collins
OSTI ID:
6347839
Report Number(s):
CONF-820582-
Conference Information:
Journal Name: Adv. Space Res.; (United States) Journal Volume: 3
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASTRONAUTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
FIBROBLASTS
HEAVY IONS
IONS
MAMMALS
MONKEYS
ORGANS
PERSONNEL
PRIMATES
RABBITS
RADIATION EFFECTS
SKIN
SOMATIC CELLS
VERTEBRATES