Chemical and biological studies on nucleic acid derivatives. Progress report, August 1, 1977--July 31, 1978

Technical Report · Tue Aug 01 00:00:00 EDT 1978

OSTI ID:6345321

Brown, G B; Parham, J C

Adenine 1-oxide is produced in the presence of cis-5-hydroxy-6-hydroperoxy-5,6-dihydrothymine under ambient conditions. The formation of the N-oxide is greatest at pH 5 to 6, but is still significant at pH 7. Time studies on the formation of adenine 1-oxide in the presence of dilute H/sub 2/O/sub 2/ at pH 5 and pH 7 indicate that the reaction is complete within 24 hr. Several possible routes for the total synthesis of 7-hydroxyadenine, a reported radiolysis and peroxide product of adenine, have been explored.

• Research Organization: Sloan-Kettering Inst. for Cancer Research, New York (USA)
• OSTI ID: 6345321
• Report Number(s): COO-2931-3
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
ADENINES
AMINES
AZINES
CHEMICAL REACTION YIELD
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXY COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PEROXIDES
PH VALUE
PURINES
PYRIMIDINES
SYNTHESIS
THYMINE
URACILS
YIELDS