Evidence for a perilymphatic origin of the endolymph: application to the pathophysiology of Meniere's disease

Journal Article · · Am. J. Otolaryngol.; (United States)

DOI:https://doi.org/10.1016/S0196-0709(82)80012-4· OSTI ID:6340739

Sterkers, O; Saumon, G; Tran Ba Huy, P; Amiel, C

The origin of the endolymph was elucidated by kinetic studies of the entry of water and electrolytes into endolymph and perilymph after intravenous administration of radioactive tracers in rats. The compartmental analysis of the data and the comparison of this study with the results of Konishi and associates using perilymphatic perfusion of tracers, indicate that perilymph rather than plasma may be considered the precursor of endolymph. Since the cochlear epithelium was found to be freely permeable to water, an alteration of electrolyte transportation across the membranous labyrinth may be involved in the pathophysiology of Meniere's disease. Chloride transport across the cochlear epithelium was investigated using acetazolamide, a specific carbonic anhydrase inhibitor.

• Research Organization: Department of Physiology, Faculte Xavier Bichat, Universite Paris, France
• OSTI ID: 6340739
• Journal Information: Am. J. Otolaryngol.; (United States), Journal Name: Am. J. Otolaryngol.; (United States) Vol. 3:5; ISSN AJOTD
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUDITORY ORGANS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BODY
BODY FLUIDS
CHEMISTRY
DISEASES
ELECTROLYTES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEMBRANE TRANSPORT
ORGANS
OXYGEN COMPOUNDS
PATHOLOGY
PRECURSOR
RADIOISOTOPES
RATS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
WATER