Study of acute WCo, low dose rate CF-252 and CS-137 radiation on LSA ascites lymphoma in vivo

Journal Article · Fri Nov 01 04:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90282-2· OSTI ID:6333315

Maruyama, Y; Feola, J M; Magura, C; Onomura, C I; Beach, J L

Dose response curves were determined for the LSA lymphoma for acute WCo, low dose rate Cs-137 and Cf-252 radiations using in vivo survival time bioassay. Mean survival times increased with dose with a prominent oxygen effect noted for acute WCo and Cs-137. OER was lowest for Cf-252 where it was approximately 1.4. The RBEn for oxic LSA cells to Cf-252 neutrons was 3.1 for acute WCo and 4.2 for Cs-137. It was larger for hypoxic tumor and RBE was 5.3 for WCo and 5.8 for Cs-137. Survival curves based on survival data used a multitarget dose-response model for photon radiation and exponential dose-response for Cf-252 radiation. When LSA was irradiated in advanced tumor stages in vivo, Cf-252 was much more effective than acute WCo or LDR Cs-137 for increasing survival time. Tumor response in vivo matched the in vitro irradiated tumor data. No schedule dependence was observed for mixing of WCo and Cf-252 radiations.

• Research Organization: Univ. of Kentucky Medical Center, Lexington
• OSTI ID: 6333315
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALI METAL ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELEMENTARY PARTICLES
ELEMENTS
EVEN-EVEN NUCLEI
FERMIONS
HADRONS
HEAVY NUCLEI
IN VIVO
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPHOMAS
MAMMALS
MASSLESS PARTICLES
MEDICINE
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NEUTRONS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OXYGEN
PHOTONS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES