Uptake of iodine-123 MIBG by pheochromocytomas, paragangliomas, and neuroblastomas: a histopathological comparison

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6331828

Bomanji, J; Levison, D A; Flatman, W D; Horne, T; Bouloux, P M; Ross, G; Britton, K E; Besser, G M

The percentage uptake of (/sup 123/I)metaiodobenzylguanidine (MIBG) by tumors of the paraganglion system is compared with the number of neurosecretory granules (assessed by both light and electron microscopy) in the subsequently resected tumors in six patients. Iodine-123 MIBG was injected intravenously; the tumor uptake of (/sup 123/I)MIBG varied between 0.001% and 0.14% of the injected dose per gram of tumor tissue at 22 hr. The number of neurosecretory granules in tissue sections was scored on a scale of I-III. A direct proportional correlation was found between the percentage uptake of (/sup 123/I)MIBG by the tumor and the number of neurosecretory granules in the tissue sections but not with plasma or urinary catecholamines. This technique for imaging reflects the storage status of the tumor better than plasma and urinary catecholamine measurements.

• Research Organization: St Bartholomew's Hospital, London, England
• OSTI ID: 6331828
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AROMATICS
AZAARENES
BETA DECAY RADIOISOTOPES
COMPARATIVE EVALUATIONS
DIAGNOSIS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GUANINE
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PROCESSING
PURINES
RADIOISOTOPES
UPTAKE