Quantitative study of radioiodinated metaiodobenzylguanidine uptake in children with neuroblastoma: Correlation with tumor histopathology

Journal Article · Sat Apr 01 04:00:00 EST 1989 · J. Nucl. Med.; (United States)

OSTI ID:5820925

Moyes, J S; Babich, J W; Carter, R; Meller, S T; Agrawal, M; McElwain, T J

Six children with neuroblastoma and one with ganglioneuroma received (/sup 125/I) metaiodobenzylguanidine (MIBG) before major surgery. Uptake of (/sup 125/I)MIBG in the excised tissues was measured by scintillation counting, and the material was submitted for histopathology. The ranges of uptake of (/sup 125/I)MIBG, expressed as percent of the injected dose per gram of tissue, were as follows: for neuroblastoma 0.0013-0.071, for ganglioneuroma 0.0017-0.0028, and for non-neoplastic control tissues 0.0002-0.011. The quantitative uptake of (/sup 125/I)MIBG by neuroblastoma varied between different patients and between different parts of individual tumors. The more undifferentiated tumors took up more (/sup 125/I)MIBG and may be more likely to respond to targeted radiotherapy with MIBG.

• Research Organization: Royal Marsden Hospital, Sutton, Surrey (England)
• OSTI ID: 5820925
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
AGE GROUPS
BETA DECAY RADIOISOTOPES
BODY
CHILDREN
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYMPH NODES
LYMPHATIC SYSTEM
METASTASES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTILLATION COUNTING
UPTAKE