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Distribution of indium in the central and peripheral nervous system of the young rat

Journal Article · · Neurotoxicology (Park Forest South, Ill.); (United States)
OSTI ID:6331049
; ; ; ;
A subtoxic quantity of radioactive In and stable indium was injected once into young rats. Subsequently pairs of these rats were killed at intervals of 15 minutes to 3 days after the injection. Tissues from the central (CNS) and peripheral nervous system (PNS) and blood were removed from each rat and the amount of In was measured in the tissues. Cryostat sections of the cerebrum, cerebellum, spinal cord, sciatic nerve, a blood smear and a kidney control from each rat were examined with an analytical ion microscope (secondary ion mass spectrometry analysis) and the presence of TIn and VIn was localized in the tissues. These observations show that indium penetrates all neural tissues and that the brain resists the entry of indium - a very toxic element - much more effectively than the sciatic nerve.
Research Organization:
Thomas Jefferson Univ., Philadelphia, PA
OSTI ID:
6331049
Journal Information:
Neurotoxicology (Park Forest South, Ill.); (United States), Journal Name: Neurotoxicology (Park Forest South, Ill.); (United States) Vol. 3; ISSN NRTXD
Country of Publication:
United States
Language:
English

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Related Subjects

560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRUM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM 113
INDIUM 115
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ION MICROSCOPY
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
NERVES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
SCIATIC NERVE
SPINAL CORD
STABLE ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES