The distribution and localization of /sup 127/m tellurium in normal and pathological nervous tissues of young and adult rats

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Neurotoxicology; (United States)

OSTI ID:5741138

Duckett, S

An equal amount (per weight) of /sup 127/m tellurium (Te) was injected IP into weanling and adult rats, some intoxicated with a diet containing Te, others not. The young intoxicated rats presented a segmental demyelination of the sciatic nerve and paralysis of the hind limbs; the adult intoxicated rats did not. Quantitation of 127m Te in nervous and other tissues was done with a gamma counter. Correlative morphological examination of the nervous tissues was done with light and electron microscopy. This study shows that Te crosses the vascular wall without injuring endothelial cells and invades the surrounding sciatic nerve parenchyma following administration of 127m Te to a weanling or adult rat. However, Te damages the endothelium, crosses the vascular wall of endo and perineurial vessels in weanling rats, causes a perivascular oedema, cytoplasmic anomalies in the Schwann cells, destruction of myelin and apparently invades axones--according to autoradiographic studies--following the administration of 127m Te plus the Te-diet. It is concluded that Te penetrates more quickly and in larger amounts the walls of blood vessels in the sciatic nerve of weanling rats intoxicated with Te, than the same nerve in the other weanling and adults rats. Te in the amounts indicated here penetrates the parenchyma of the CNS but apparently does not cause injury.

• Research Organization: Department of Neurology, Faculty of Medicine, Thomas Jefferson University, Philadelphia, PA
• OSTI ID: 5741138
• Journal Information: Neurotoxicology; (United States), Journal Name: Neurotoxicology; (United States) Vol. 3:3; ISSN NRTXD
• Country of Publication: United States
• Language: English

Related Subjects

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
ELEMENTS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NERVES
NERVOUS SYSTEM
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RATS
RODENTS
SCIATIC NERVE
SEMIMETALS
TELLURIUM
TELLURIUM 127
TELLURIUM ISOTOPES
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
VERTEBRATES