Dacron arterial grafts: the influence of porosity, velour, and maturity on thrombogenicity

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Surgery; (United States)

OSTI ID:6328506

Goldman, M; McCollum, C N; Hawker, R J; Drolc, Z; Slaney, G

It has been claimed that the neointimal healing of Dacron arterial prostheses can be enhanced by increasing porosity and including both an internal and an external velour layer. To test this, 24 patients received at random either woven or more porous, double-velour, knitted Dacron aortobifemoral prostheses. Graft thrombogenicity was measured using autogenous /sup 111/In-labeled platelets shortly following surgery and 6 to 9 months later. The thrombogenicity index was defined as the mean daily rise in the ratio of emissions over the graft to emissions over a reference area (aortic arch) and is a measure of platelet deposition. At early study the mean (+/- SE) thrombogenicity index was similar in woven and knitted graft patients at 0.19 +/- 0.4 and 0.14 +/- 0.2, respectively. In both groups it was lower (P less than 0.05) 6 to 9 months later at 0.06 +/- 0.2 (woven( and 0.08 +/- 0.1 (knitted), with again no difference between materials. Although platelet survival was restored to near normal values in both groups by 6 to 9 months, only one woven graft failed to demonstrate continued platelet accumulation by gamma-imaging. Thrombogenicity in Dacron grafts diminishes in the early months of maturation but is not affected by porosity and velour. Moreover, this thrombogenicity persists beyond the period of altered platelet survival.

• Research Organization: Department of Surgery, Queen Elizabeth Medical Centre, Birmingham, United Kingdom
• OSTI ID: 6328506
• Journal Information: Surgery; (United States), Journal Name: Surgery; (United States) Vol. 92:6; ISSN SURGA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AORTA
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CHEMICAL COMPOSITION
COMPARATIVE EVALUATIONS
DACRON
DAYS LIVING RADIOISOTOPES
DESIGN
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
GRAFTS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MEASURING METHODS
MEDICAL SUPPLIES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PATIENTS
PERFORMANCE
PHYSIOLOGY
POLYESTERS
POLYMERS
POROSITY
PROSTHESES
RADIOISOTOPES
TRANSPLANTS