Platelet reactivity in human aortic grafts: a prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

Journal Article · Wed Feb 01 04:00:00 EST 1989 · J. Vasc. Surg.; (United States)

DOI:https://doi.org/10.1016/0741-5214(89)90042-6· OSTI ID:6326474

Wakefield, T W; Shulkin, B L; Fellows, E P; Petry, N A; Spaulding, S A; Stanley, J C

Platelet-related phenomena at the blood-surface interface of randomly placed knitted Dacron (n = 6) and polytetrafluoroethylene (ePTFE) (n = 6) interposition aortic grafts were studied in patients undergoing abdominal aortic aneurysmectomy. Luminal accumulation of platelets was assessed by infusing indium-111-oxine (400 microCi) labeled autologous platelets and imaging grafts at 1 week, 3 months, and 6 months after surgery. Image analysis included an indium ratio technique (comparing aortic graft radioactivity to that of an iliac artery) and a red blood cell technetium subtraction technique (excluding blood pool radioactivity from graft radioactivity, with the heart or iliac artery serving as reference regions). Plasma levels of beta-thromboglobulin and platelet factor 4 were correlated with platelet accumulations on the aortic prostheses. Differences in graft radioactivity or platelet-release products were not evident 1 week after surgery. Three months after implantation, Dacron and ePTFE conduits exhibited 87% and 47% (p less than 0.05) more radioactivity with the indium ratio technique than the iliac artery. Similarly, increased Dacron compared with ePTFE graft radioactivity was noted using technetium subtraction techniques: 71% vs 30% with a heart reference and 26% vs 11% with an iliac artery reference, respectively. Increases in graft radioactivity correlated with increases in both plasma beta-thromboglobulin and platelet factor 4 at 3 months (r = 0.6 to 0.9; p less than 0.05 to 0.001 depending on the imaging technique used). At 6 months, differences did not persist. In fact, technetium subtraction techniques suggested less Dacron conduit reactivity. It is speculated that differences in platelet accumulation and activation associated with different graft substrates may prove clinically important.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor (USA)
• OSTI ID: 6326474
• Journal Information: J. Vasc. Surg.; (United States), Journal Name: J. Vasc. Surg.; (United States) Vol. 9:2; ISSN JVSUE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
ADHESION
ANIMALS
AORTA
AROMATICS
ARTERIES
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY AREAS
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COAGULANTS
DACRON
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
ESTERS
FLUORINATED ALIPHATIC HYDROCARBONS
GLOBULINS
GRAFTS
HALOGENATED ALIPHATIC HYDROCARBONS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMAGE PROCESSING
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MATERIALS
MEDICAL SUPPLIES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
OXINE
PATIENTS
POLYESTERS
POLYETHYLENES
POLYMERS
POLYOLEFINS
POLYTETRAFLUOROETHYLENE
PRIMATES
PROCESSING
PROSTHESES
PROTEINS
PYRIDINES
QUINOLINES
RADIOISOTOPES
TECHNETIUM ISOTOPES
TRANSPLANTS
VASCULAR DISEASES
VERTEBRATES