Adaptation of cell renewal systems under continuous irradiation

Journal Article · Fri May 01 04:00:00 EDT 1987 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198705000-00006· OSTI ID:6328207

Fabrikant, J I

There are adaptive changes in the proliferative characteristics of renewal tissues under the stress of continuous low-dose-rate irradiation which indicate that cell and tissue kinetics will have a considerable effect on the radiation response. Factors that determine the adaptation response involve cellular radiosensitivity, i.e. cell cycle effects, which determine the rate of cell sterilization and death, and compensatory cell proliferation and the capacity for regeneration, i.e. changes in the patterns of cell population kinetics, which determine the rate of cell birth. In rapidly dividing cell renewal systems, there is an effective elimination of damaged cells, with almost complete repair of cellular nonlethal damage. In slowly dividing renewal tissues, there is some repair or elimination of cellular radiation damage and the pattern of cell proliferation during regeneration is relatively little disturbed by prior continuous irradiation. Experimental data on intestinal epithelium, immunohematopoietic tissues, seminiferous epithelium and regenerating liver are presented. Discussion includes differences in adaptation to continuous low-dose-rate irradiation involving intracellular and extracellular control mechanisms which regulate cellular proliferation and differentiation and, thereby, control cell population levels and physiological function. 29 references.

• Research Organization: Univ. of California, Berkeley
• OSTI ID: 6328207
• Journal Information: Health Phys.; (United States), Journal Name: Health Phys.; (United States) Vol. 5; ISSN HLTPA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BIOLOGICAL REPAIR
BODY
CELL CYCLE
CELL DIVISION
CELL KILLING
CELL PROLIFERATION
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DIGESTIVE SYSTEM
DOSE RATES
EPITHELIUM
GAMETES
GASTROINTESTINAL TRACT
GERM CELLS
GLANDS
INJURIES
INTESTINES
IRRADIATION
LIVER
LOW DOSE IRRADIATION
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
SPERMATOGONIA
STEM CELLS
TISSUES