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Effector and suppressor circuits of the immune response are activated in vivo by different mechanisms

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
;

The application of fluorescein isothiocyanate (FITC) onto the skin of mice induces a contact hypersensitivity immune response. Lymph nodes draining the skin painted with FITC contain fluorescent cells that induce contact hypersensitivity to FITC when injected into normal mice. The antigen-presenting cells responsible for activating the effector pathway of the contact hypersensitivity response express Ia histocompatibility determinants and are resistant to inactivation with gamma-radiation. Exposing the skin to low doses of UV radiation (280-320 nm) before the application of FITC suppresses the contact hypersensitivity response to FITC. Cells present in the draining lymph nodes of these mice induce suppressor T lymphocytes when injected into normal recipients. The inducer cells in the draining lymph nodes are Thy 1+, Ia- and are inactivated by gamma-radiation. These studies demonstrate that different mechanisms are involved in the in vivo activation of effector and suppressor immune responses, and they suggest that the mode of initial antigen presentation determines which immunologic circuit will be activated in response to a contact-sensitizing antigen.

Research Organization:
Univ. of Texas System Cancer Center, Houston
OSTI ID:
6327489
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 11; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
ANTITHYROID DRUGS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
CONNECTIVE TISSUE CELLS
DRUGS
DYES
ELECTROMAGNETIC RADIATION
FLUORESCEIN
GAMMA RADIATION
HORMONE ANTAGONISTS
HYDROXY ACIDS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNITY
IN VIVO
IONIZING RADIATIONS
LEUKOCYTES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSITIVITY
SKIN
SOMATIC CELLS
THIOCYANATES
ULTRAVIOLET RADIATION
VERTEBRATES