Radioenzymatic analysis of neurotransmitters
Since the late 1960's, radioenzymatic assays have gradually come to replace the less sensitive and less specific spectrofluorometric and bioassay procedures previously used to determine many of the neurotransmitters. These assays provide the means to measure picogram quantities of most of these substances, and have enabled determinations to be made in very small volumes of body fluids, in brain perfusates and individual brain nuclei, and in large individual cells of some simple animals. This paper reviews briefly some of the radioenzymatic techniques presently available for assaying norepinephrine (NE), epinephrine (E), dopamine (DA), serotonin, and the trace amines octopamine (OA), phenylethanolamine (PEOHA), phenylethylamine (PEA), tyramine (TA) and tryptamine (T).
- Research Organization:
- Univ. of Saskatchewan, Saskatoon
- OSTI ID:
- 6326876
- Journal Information:
- Life Sci.; (United States), Vol. 41:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADRENALINE
RADIOENZYMATIC ASSAY
AMINES
DOPAMINE
NORADRENALINE
SEROTONIN
BODY FLUIDS
BRAIN
ADRENAL HORMONES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL MATERIALS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
MATERIALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRYPTAMINES
550201* - Biochemistry- Tracer Techniques