Radioresistance in some human tumor cells conferred in vitro by repair of potentially lethal x-ray damage

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.145.2.7134460· OSTI ID:6325845

Weichselbaum, R R; Little, J B

In vitro x-ray survival curves were obtained from plateau-phase cultures of a human melanoma cell line and a human breast cancer cell line. After immediate subculture no radioresistance was seen in either cell line. After a 24-hour delay in subculture the melanoma cell line developed significant radioresistance but the breast cancer cell line did not. We concluded that the radioincurability of some melanomas may be due to radioresistance that occurs as a result of potentially lethal damage repair.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6325845
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 145:2; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGY
CELL KILLING
ELECTROMAGNETIC RADIATION
IN VITRO
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
RADIATIONS
RADIOBIOLOGY
RADIOINDUCTION
RADIOSENSITIVITY
RECOVERY
REPAIR
SURVIVAL CURVES
TUMOR CELLS
X RADIATION