Inherently radioresistant cells exist in some human tumors

Journal Article · Mon Jul 01 04:00:00 EDT 1985 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.82.14.4732· OSTI ID:6081990

Weichselbaum, R R; Dahlberg, W; Little, J B

The authors investigated the survival of 29 human tumor cell lines after treatment with ionizing radiation during exponential growth. The radiosensitivity of 20 tumor cell lines was within the range of normal fibroblasts. However, 9 cell lines derived from radio-incurable tumors appeared inherently radioresistant. When the ability to repair potentially lethal x-ray damage was studied in plateau phase cultures, some tumor cell lines derived from radio-incurable tumors were more efficient in this process. These results indicate that the presence of radioresistant and/or repair-proficient cells, which exist in some human tumors, may be responsible for failure to obtain local control following therapeutic x-ray treatment.

• Research Organization: Harvard School of Public Health, Boston, MA
• OSTI ID: 6081990
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 82:14; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGY
DNA REPAIR
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MEDICINE
NUCLEAR MEDICINE
RADIATIONS
RADIOBIOLOGY
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RECOVERY
REPAIR
SURVIVAL CURVES
THERAPY
TUMOR CELLS
X RADIATION