Individual differences in regional deposition of 6-micron particles in humans with induced bronchoconstriction

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Exp. Lung Res.; (United States)

DOI:https://doi.org/10.3109/01902148909069613· OSTI ID:6323644

Svartengren, M; Philipson, K; Camner, P

The effect of induced bronchoconstriction on regional lung deposition of 6 microns aerodynamic diameter 99mTc-labeled Teflon particles was studied in eight healthy non-smokers. The Teflon particles were inhaled at 0.5 l/s from a 25-l glass bulb with 8-12 maximally deep breaths on four consecutive days. For three exposures, various degrees of bronchoconstriction were induced using an aerosol of methacholine bromide before the inhalation of the Teflon particles. For the fourth (control) exposure, bronchoconstriction was induced after the inhalation of the Teflon particles. The degree of bronchoconstriction was quantified by measurements of airway resistance (Raw) using a whole-body plethysmograph. The fraction of alveolarly deposited particles in the lung (FAD) was estimated by measurements of radioactivity in the lung immediately after inhalation of the Teflon particles and 6 h later. Earlier studies have shown that when the mucociliary transport is stimulated with the cholinergic aerosol used in this study, the 6-h retention values (Ret6) are similar to the 24-h values. Within the subjects there was a close relationship between Raw and Ret6 with a decrease of Ret6 with increased Raw. This decrease varied markedly among the subjects. The relationship between Raw and Ret6 calculated from the model by the Task Group on Lung Dynamics, in which the airway diameters were varied, agreed with our experimental data. On an average, airway resistance of 1 and 2 cm H2O.s/l correspond to FAD of about 50% and 25%, respectively.

• Research Organization: Karolinska Institute, Stockholm (Sweden)
• OSTI ID: 6323644
• Journal Information: Exp. Lung Res.; (United States), Journal Name: Exp. Lung Res.; (United States) Vol. 15:1; ISSN EXLRD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRONCHI
FLUORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MAN
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
PARTICLE SIZE
PARTICLES
PARTICULATES
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYETHYLENES
POLYMERS
POLYOLEFINS
POLYTETRAFLUOROETHYLENE
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM
RETENTION
SIZE
SYNTHETIC MATERIALS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TEFLON
TRACER TECHNIQUES
VASOCONSTRICTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES