In vivo toxicity of 3 prime -azido-3 prime -deoxythymidine (AZT) on CBA/Ca mice
- Brookhaven National Laboratory, Upton, NY (USA)
CBA/Ca male mice were given 3'-azido-3'-deoxythymidine (AZT) in drinking water (1 mg/ml) for up to 7 weeks. Water consumption and body weight decreased significantly. Neutropenia and lymphopenia were observed during and after exposure. Significant macrocytic anemia developed and disappeared as a function of red cell life span after stopping AZT intake. A microthrombocytosis was seen. Bone marrow cellularity and spleen colony-forming unit (CFU-s) content fell, but recovered completely and quickly after terminating AZT intake. Hemopoietic stem cell function measured by 2 different methods of rescuing fatally irradiated mice was normal 4 weeks after AZT exposure, suggesting that AZT treatment does not induce a long-lasting effect in genetic control of mitotic potential of stem cells. This is in marked contrast to exposure of CBA/Ca mice to benzene and ionizing radiation.
- OSTI ID:
- 6323592
- Journal Information:
- International Journal of Cell Cloning; (USA), Journal Name: International Journal of Cell Cloning; (USA) Vol. 8:5; ISSN 0737-1454; ISSN IJCCE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL DIVISION
COLONY FORMATION
ERYTHROCYTES
HETEROCYCLIC COMPOUNDS
IN VIVO
MAMMALS
MATERIALS
MICE
MITOSIS
NUCLEOSIDES
NUCLEOTIDES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATIC CELLS
SPLEEN CELLS
STEM CELLS
THYMIDINE
TOXICITY
VERTEBRATES