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Evoked trigeminal nerve potential in chronic trichloroethylene intoxication

Journal Article · · J. Toxicol., Clin. Toxicol.; (United States)
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Results of a study of trigeminal nerve impairment resulting from trichloroethylene intoxication by the somatosensory-evoked potential method reveal three kinds of abnormalities: increased stimulation voltage, excessive latency delay with morphological abnormalities, and excessive graph amplitude. These abnormalities confirm clinical disturbance (hypesthesia of the trigeminal nerve area) and open debate about the real mechanism of trichloroethylene neurotoxicity. Industrial intoxication by solvents, particularly trichloroethylene, is common. We have conducted a study of 188 workers chronically exposed to trichloroethylene and have confirmed the selective neurological disturbances of this intoxication in the trigeminal nerve (20%) (3, 10). We utilized a new experimental method, developed for studies of chronic intoxications effecting the median nerve (5, 8), of recording the somatosensory evoked potential following stimulation of the trigeminal nerve (4, 6, 7). The workers in this study were selected following clinical evaluation of their facial sensitivity and trigeminal nerve reflexes. In this paper we present our preliminary results on 11 workers, 9 suffering effects of intoxication and 2 controls.

Research Organization:
Service de Medecine Interne et Toxicologie, C.H.R. de Grenoble, France
OSTI ID:
6323381
Journal Information:
J. Toxicol., Clin. Toxicol.; (United States), Journal Name: J. Toxicol., Clin. Toxicol.; (United States) Vol. 19:4; ISSN JTCTD
Country of Publication:
United States
Language:
English

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Related Subjects

550800 -- Morphology
551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOELECTRICITY
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CHEMICAL INDUSTRY
CHLORINATED ALIPHATIC HYDROCARBONS
ELECTRICITY
HALOGENATED ALIPHATIC HYDROCARBONS
INDUSTRY
MORPHOLOGICAL CHANGES
NERVES
NERVOUS SYSTEM
OCCUPATIONAL SAFETY
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PERSONNEL
SAFETY
SENSITIVITY
TOXICITY