Analyses of critical target cell responses during preclinical phases of evolving chronic radiation-induced myeloproliferative disease-exploitation of a unique canine model

Conference · Fri Jan 01 00:00:00 EST 1988

OSTI ID:6322953

Seed, T M; Kaspar, L V; Tolle, D V; Fritz, T E; Frazier, M E

This document briefly summarizes and highlights ongoing studies on the cellular and molecular processes involved in the induction and progression of myeloid leukemia in dogs chronically exposed to low daily doses of wholebody gamma irradiation. Under such conditions, select groups of dogs exhibit extremely high frequencies of myeloproliferative disease (MPD) (i.e., /congruent/50%) of which myeloid leukemia is most prominent. 2 figs.

• Research Organization: Argonne National Lab., IL (USA); Battelle Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6322953
• Report Number(s): CONF-881070-3; ON: DE89007503; TRN: 89-008804
• Resource Relation: Conference: Symposium on multi-level health effects research: molecules to man, Richland, WA, USA, 17 Oct 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOASSAY
NEOPLASMS
RADIOINDUCTION
DOGS
GAMMA RADIATION
LEUKEMOGENESIS
LOW DOSE IRRADIATION
TRANSFORMATIONS
ANIMALS
CARCINOGENESIS
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
PATHOGENESIS
RADIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals