skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Bone marrow scintigraphy and computed tomography in myloproliferative disease

Abstract

Peripheral bone marrow (BM) expansion in myeloproliferative disease (MPD) is demonstrated by scintigraphy (scint) with Technetium 99m sulfur colloid (TSC) or Indium III chloride (In). Computed tomography (CT) of the normal adult medullary cavity yields negative attenuation coefficients (AC) which become positive when BM fat is replaced. BM scint and CT of the medullary cavity are obtained in 23 studies in 21 pts: 6 polycythemia vera (PCV), 6 post PCV myeloid metaplasis (MyM), 4 agnogenic MyM, 3 myelodysplasia with refractory anemia, 1 acute myelocytic leukemia and 1 chronic myelocytic with acute leukemic transformation. AC were measured for BM cavity of lower extremities at each third of the femur and tibia. Values ranged from -89 to +289 Hounsfield units. The results are presented in this paper. There was agreement between SCINT and CT in 83% pts and segments. 80% of MB segments with + AC had scint identified BM. BM biopsy of the iliac crest demonstrated fibrosis or blast proliferation in pts with +AC rather than hypercellularity or osteosclerosis. The highest AC values (>200) were seen in pts with blast proliferation and fibrosis. Decreased BM scint visualization and +CT AC correlated with BM fibrosis and may reflect replacement of BM elementsmore » or decreased RES function. BM scint and CT are useful to monitor MPD and select BM sites for biopsy.« less

Authors:
; ;
Publication Date:
Research Org.:
Mt. Sinai Medical Center, New York, NY
OSTI Identifier:
5976098
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-039208
Resource Type:
Conference
Resource Relation:
Journal Name: J. Nucl. Med.; (United States); Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW; CAT SCANNING; CELL PROLIFERATION; SCINTISCANNING; OSTEOMYELITIS; DIAGNOSIS; SKELETAL DISEASES; COLLOIDS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC USES; HEMIC DISEASES; SULFUR COMPOUNDS; TECHNETIUM 99; ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DISPERSIONS; HEMATOPOIETIC SYSTEM; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TISSUES; TOMOGRAPHY; USES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

Goldsmith, S.J., Gilbert, H.S., and Hermann, G.. Bone marrow scintigraphy and computed tomography in myloproliferative disease. United States: N. p., 1985. Web.
Goldsmith, S.J., Gilbert, H.S., & Hermann, G.. Bone marrow scintigraphy and computed tomography in myloproliferative disease. United States.
Goldsmith, S.J., Gilbert, H.S., and Hermann, G.. Wed . "Bone marrow scintigraphy and computed tomography in myloproliferative disease". United States. doi:.
@article{osti_5976098,
title = {Bone marrow scintigraphy and computed tomography in myloproliferative disease},
author = {Goldsmith, S.J. and Gilbert, H.S. and Hermann, G.},
abstractNote = {Peripheral bone marrow (BM) expansion in myeloproliferative disease (MPD) is demonstrated by scintigraphy (scint) with Technetium 99m sulfur colloid (TSC) or Indium III chloride (In). Computed tomography (CT) of the normal adult medullary cavity yields negative attenuation coefficients (AC) which become positive when BM fat is replaced. BM scint and CT of the medullary cavity are obtained in 23 studies in 21 pts: 6 polycythemia vera (PCV), 6 post PCV myeloid metaplasis (MyM), 4 agnogenic MyM, 3 myelodysplasia with refractory anemia, 1 acute myelocytic leukemia and 1 chronic myelocytic with acute leukemic transformation. AC were measured for BM cavity of lower extremities at each third of the femur and tibia. Values ranged from -89 to +289 Hounsfield units. The results are presented in this paper. There was agreement between SCINT and CT in 83% pts and segments. 80% of MB segments with + AC had scint identified BM. BM biopsy of the iliac crest demonstrated fibrosis or blast proliferation in pts with +AC rather than hypercellularity or osteosclerosis. The highest AC values (>200) were seen in pts with blast proliferation and fibrosis. Decreased BM scint visualization and +CT AC correlated with BM fibrosis and may reflect replacement of BM elements or decreased RES function. BM scint and CT are useful to monitor MPD and select BM sites for biopsy.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 26:5,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1985},
month = {Wed May 01 00:00:00 EDT 1985}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share:
  • A prospective evaluation of conventional planar scintigraphy (PS), single photon emission computed tomography (SPECT), and transmission computed tomography (TCT) was performed in 98 patients with suspected focal hepatic disease (FHD). The three examinations were performed on the same day. TCT had slightly higher sensitivity (91%) and specificity (96%) than either PS or SPECT. The sensitivy and specificity of TCT was also higher than that of the combination of PS and SPECT, which was more accurate than either radionuclide technique alone, with a sensitivity of 85-87% and a specificity of 90%. These differences were not statistically significant. However, receiver operating characteristicmore » (ROC) analysis showed that the performance of TCT was significantly better.« less
  • Computed tomography and serial scintigraphy with /sup 99m/Tc-pertechnetate (radionuclide angiography and early and late static imaging) were compared in 214 patients with cerebrovascular disease. CT correctly identified 151 (95.0%) of 159 patients with completed ischemic stroke but was positive in only 11 (25%) of 44 patients with asymptomatic stenosis, transient ischemic attacks (TIA), or prolonged reversible ischemic neurological deficit (PRIND). Scintigraphy was positive in 93.1% of patients with completed stroke. CT detected 175 territories of vascular supply involved, scintigraphy 164. In patients with asymptomatic stenosis, TIA, or PRIND, scintigraphy was correct in 77.3% of cases. The combined evaluation offered amore » sensitivity of 97.5% in patients with completed stroke and 86.4% in those with asymptomatic stenosis, TIA, or PRIND. The rate of true-positive scintigraphic findings in patients with completed stroke did not change as the interval between ictus and study increased. In patients with intracerebral hematoma, CT was far more specific than scintigraphy. If cerebrovascular disease is suspected, radionuclide angiography should be performed first.« less
  • Twenty-seven patients with angina pectoris, 24 with postmyocardial infarction angina and 7 with normal coronary arteries were examined by exercise thallium-201 emission computed tomography (SPECT) and planar scintigraphy. Exercise SPECT was compared with the reperfusion imaging obtained approximately 2 to 3 hours after exercise. The sensitivity and specificity of demonstrating involved coronary arteries by identifying the locations of myocardial perfusion defects were 96 and 87% for right coronary artery, 88 and 89% for left anterior descending artery (LAD) and 78 and 100% for left circumflex artery (LC). These figures are higher than those for planar scintigraphy (85 and 87% formore » right coronary artery, 73 and 89% for LAD and 39 and 100% for LC arteries). In patients with 3-vessel disease, sensitivity of SPECT (100, 88 and 75% for right coronary artery, LAD and LC, respectively) was higher than planar imaging (88, 63 and 31%, respectively), with a significant difference for LC (p less than 0.05). In 1, 2 and 0-vessel disease the sensitivity and specificity of the 2 techniques were comparable. Multivessel disease was more easily identified as multiple coronary involvement than planar imaging with a significant difference in 3-vessel disease (p less than 0.05). In conclusion, stress SPECT provides useful information for the identification of LC lesions in coronary heart disease, including 3-vessel involvement.« less
  • Three cases of talocalcaneal coalition were evaluated with routine radiography, conventional tomography, /sup 99m/Tc-MDP bone scintigraphy, and computed tomography (CT). Routine radiography was normal in 1 case and demonstrated secondary findings suggesting coalition in 2. Conventional tomography confirmed the coalition in 2 patients. In all 3 cases, the scintigrams demonstrated increased uptake in the region of the coalition. CT provided the most graphic depiction of the coalition site and also identified an associated lesion involving the posterior subtalar joint, not recognized on conventional tomography. Scintigraphy may be useful as a screening procedure and can provide important localizing information in difficultmore » cases.« less
  • Three cases of talocalcaneal coalition were evaluated with routine radiography, conventional tomography, /sup 99m/Tc-MDP bone scintigraphy, and computed tomography (CT). Routine radiography was normal in 1 case and demonstrated secondary findings suggesting coalition in 2. Conventional tomography confirmed the coalition in 2 patients. In all 3 cases, the scintigrams demonstrated increased uptake in the region of the coalition. CT provided the most graphic depiction of the coalition site and also identified an associated lesion involving the posterior subtalar joint, not recognized on conventional tomography. Scintigraphy may be useful as screening procedure and can provide important localizing information in difficult cases.