Clinical experiences in the treatment of neuroblastoma with sup 131 I-metaiodobenzylguanidine

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Pediatric Hematology and Oncology; (USA)

DOI:https://doi.org/10.3109/08880018609031220· OSTI ID:6322042

Treuner, J; Klingebiel, T; Feine, U; Buck, J; Bruchelt, G; Dopfer, R; Girgert, R; Mueller-Schauenburg, W M; Meinke, J; Kaiser, W ^[1]

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1. Pediatric University Hospital, Tuebingen (West Germany)

Treatment of neuroblastoma is an unsolved problem of pediatric oncology. In spite of highly intensified chemotherapy, the long-term survival rate of children with a metastatic neuroblastoma is below 10%. We therefore used {sup 131}I-metaiodobenzylguanidine (MIBG) for the first time to treat children with a neuroblastoma in relapse or primary unresponsiveness to chemotherapy. We had previously demonstrated that MIBG is useful for the scintigraphic imaging of neuroblastoma lesions and had investigated the cytotoxicity and uptake of MIBG in various neuroblastoma cell lines. We treated 6 children with neuroblastoma in a total of 19 courses. Three of the children suffered from a relapse of neuroblastoma; 3 had never gained a remission. Four of the 6 children lost their bone pain and fever during the first 3 days. In 5 of the 6 children the solid tumor as well as the bone marrow infiltration responded to MIBG treatment, with responses ranging from transitory decrease of the tumor mass to complete disappearance of abdominal tumors. We also witnessed a stabilization of osteolytic lesions, a decrease in elevated serum catecholamines, and a decrease in bone marrow infiltration. Five of the 6 children died of tumor progression 55-249 days after the first MIBG treatment.

• OSTI ID: 6322042
• Journal Information: Pediatric Hematology and Oncology; (USA), Journal Name: Pediatric Hematology and Oncology; (USA) Vol. 3:3; ISSN PHONE; ISSN 0888-0018
• Country of Publication: United States
• Language: English

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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
AMINES
ANIMAL TISSUES
AROMATICS
AUTONOMIC NERVOUS SYSTEM
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
CATECHOLAMINES
CHILDREN
DAYS LIVING RADIOISOTOPES
DISEASES
HEMATOPOIETIC SYSTEM
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POST-IRRADIATION EXAMINATION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
TISSUES